mod_wsgi + Flask28 Jan 2015Here’s my mod_wsgi configuration for a flask app that uses Flask-Admin.WSGIDaemonProcess makermanager2 user=www-data group=www-data threads=5 WSGIScriptAlias /makermanager2 /var/www/makermanager2/runserver.wsgi <Directory /var/www/makermanager2> WSGIProcessGroup makermanager2 WSGIApplicationGroup %{GLOBAL} Order deny,allow Allow from all </Directory> Alias /makermanager2/assets /var/www/makermanager2/application/static <Directory /var/www/makermanager2/application/static> Order allow,deny Allow from all </Directory> Alias /makermanager2/static/admin /opt/Envs/prod/src/flask-admin-master/flask_admin/static/ <Directory /opt/Envs/prod/src/flask-admin-master/flask_admin/static/> Order allow,deny Allow from all </Directory> Trailing slashes matter! If you set a trailing slash, it will only set the alias for that directory and not all of the directories below it.